Recent Advances in Direct C–H Functionalization of Pyrimidines

Author:

Verbitskiy Egor12ORCID,Rusinov Gennady12,Chupakhin Oleg12,Charushin Valery12

Affiliation:

1. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

2. Ural Federal University

Abstract

Data spanning the period 2000–2017 on the direct C–H functionalization of pyrimidines are collected and discussed in this review. This demonstrates the surge of interest and creativity that this field of chemistry has experienced during the last two decades. Plausible applications of highly functionalized pyrimidines are also discussed.1 Introduction2 Transition-Metal-Catalyzed C–H Functionalization of Pyrimidine Derivatives3 Transition-Metal-Free Direct C–H Functionalization of Pyrimidine Derivatives4 Deprotonative Metalation of Pyrimidine Derivatives5 Conclusions

Funder

Russian Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

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