Catalyst-Free Synthesis of Fused Triazolo-Diazepino[5,6-b]Quinoline Derivatives via a Sequential Ugi-4CR–Nucleophilic Substitution–Intramolecular Click Reaction

Author:

Balalaie Saeed12,Vaezghaemi Aref1,Zarezadeh Nahid1,Rominger Frank3,Bijanzadeh Hamid4

Affiliation:

1. Peptide Chemistry Research Center, K. N. Toosi University of Technology

2. Medical Biology Research Center, Kermanshah University of Medical Sciences

3. Organisch-Chemisches Institut der Universitaet Heidelberg

4. Department of Biophysics, Tarbiat Modares University

Abstract

A convenient, post-transformational reaction has been ­developed for the construction of highly diversified quinoline-fused triazolo-diazepinones featuring four diversification points by employing a catalyst-free Ugi four-component–nucleophilic substitution–intra­molecular click cycloaddition sequence. This approach provides a wide scope of products with good yields and high bond-forming efficiency.

Funder

Iran National Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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