Persistent Hyperlactatemia as the Predictor of Poor Outcome in Critically Ill Children: A Single-Center, Prospective, Observational Cohort Study-Reference-Cited by-同舟云学术

Persistent Hyperlactatemia as the Predictor of Poor Outcome in Critically Ill Children: A Single-Center, Prospective, Observational Cohort Study

Published:2016-11-10 Issue:03 Volume:06 Page:152-158
ISSN:2146-4618
Container-title:Journal of Pediatric Intensive Care
language:en
Short-container-title:J Pediatr Intensive Care

Author:

Antin Jennifer¹,Khare Shweta¹,Patki Vinayak²

Affiliation:

1. Department of Pediatrics, Wanless Hospital, Miraj, Sangli, Maharashtra, India

2. Department of Pediatrics, Institute of Medical Education and Research, Vidyagiri, Satara, Maharashtra, India

Abstract

Objective To study incidence of hyperlactatemia and its correlation with outcome in critically ill children. Design Single-center, prospective cohort study. Setting Eight-bedded PICU. Method Serial serum lactate levels were measured in 140 critically ill children at 0, 12, 24, and 48 hours. Results A total of 45% children had hyperlactatemia. Lactate levels were significantly (p = 0.000) higher in nonsurvivors at all intervals. Lactate levels decreased significantly (p = 0.000) in survivors while increased in nonsurvivors. Normalized lactate load was found to be an independent predictor of mortality (p = 0.023). Conclusion Persistent hyperlactatemia serves as a possible predictor of poor outcome in critically ill children.

Publisher

Georg Thieme Verlag KG

Subject

Critical Care and Intensive Care Medicine,Pediatrics, Perinatology and Child Health

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1593886.pdf

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Normalized lactate load as an independent prognostic indicator in patients with cardiogenic shock;BMC Cardiovascular Disorders;2024-07-10

2. Procalcitonin and blood lactate level as predictive biomarkers in pediatric multiple trauma patients’ pediatric intensive care outcomes: A retrospective observational study;Medicine;2023-12-08

3. A Retrospective Study on the Availability of Arterial Lactate Levels as a Biomarker of Mortality in Critically Ill Children;Turkish Journal of Pediatric Disease;2023-08-24

4. Initial Lactate Level Affects the Relationship between Early Lactate Measurement and mortality in Septic Patients: a Cohort Study Based on the eICU-CRD database;2022-12-15

5. Risk factors for mortality in preterm infants with necrotizing enterocolitis: a retrospective multicenter analysis;European Journal of Pediatrics;2021-10-12