Affiliation:
1. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
2. School of Life Science and Engineering, Southwest Jiaotong University
Abstract
A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.
Funder
National Natural Science Foundation of China
MOST
Shenzhen Science and Technology Innovation Committee
Shenzhen Peacock Program
Cited by
1 articles.
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