Copper-Catalyzed Aerobic Oxidation and Oxygenation of Anilines and Acetaldehydes with Dioxygen for the Concise Synthesis of 2-Aroylquinolines

Author:

Li Ziyuan12,Jiao Ning2,Wang Xiaoyang2,Ma Lifang1

Affiliation:

1. Department of Pharmaceutical and Biological Engineering, School of Chemical Engineering, Sichuan University

2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University

Abstract

A concise and efficient aerobic oxidation and oxygenation approach for the construction of 2-aroylquinolines has been developed through copper-catalyzed annulation of anilines, acetaldehydes, and dioxygen. 2,2,6,6-Tetramethylpiperidine-1-oxyl was employed to direct the selectivity toward the desired 2-aroyl products. Molecular oxygen was used in this transformation as an environmentally benign source of oxygen.

Funder

National Basic Research Program of China

Peking University Health Science Center

National Young Top-Notch Talent Support Program

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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