Affiliation:
1. Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki
2. Department of Pharmacy, University of Groningen
3. Medway School of Pharmacy, Universities of Greenwich and Kent at Medway
Abstract
An easy access to hybrid bioactive molecules, such as the chromenopyrazoles, is described based on the three-component reactions of 3-formylchromones, arylhydrazines, and acetylenedicarboxylates. By manipulating the reaction, four different scaffolds can be derived in an easy, versatile, and robust fashion. To underscore the potential, generality, and diversity that can be generated, representative libraries of each scaffold were synthesized. Moreover, a comprehensive NMR analysis with full assignment of all 1H and 13C NMR chemical shifts has been performed.
Subject
Organic Chemistry,Catalysis
Cited by
9 articles.
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