Synthesis of (±)-γ-Lycorane by Using an Intramolecular Friedel–Crafts Reaction-Reference-Cited by-同舟云学术

Synthesis of (±)-γ-Lycorane by Using an Intramolecular Friedel–Crafts Reaction

Published:2017-07-20 Issue:20 Volume:49 Page:4711-4716
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Doan Bao¹,Tan Xin¹,Ang Chin¹,Bates Roderick¹

Affiliation:

1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University

Abstract

A total synthesis of γ-lycorane has been achieved by employing N-tosylpyrrole as a key building block. The synthesis employs both an intermolecular and an intramolecular Friedel–Crafts reaction, as well as a completely diastereoselective hydrogenation of a late-stage pyrrole intermediate.

Funder

Agency for Science Technology and Research

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1589067.pdf

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