Direct Introduction of an N,N′-Nonsubstituted Carboxamidine Group by Grignard Addition to Silylated Cyanamide

Abstract

A new, widely applicable method to substitute a halogen atom by a nonsubstituted carboxamidine group is presented. Grignard addition to N,N′-bis-trimethylsilylcarbodiimide gives amidinates, which split off the silyl groups during standard aqueous workup. The corresponding amidines are obtained in high yield with high selectivity. Examples for purification procedures are given.