Affiliation:
1. College of Chemistry and Molecular Engineering, Zhengzhou University
Abstract
An efficient protocol has been developed for the cobalt-catalyzed perfluoroalkylation of 8-aminoquinoline scaffolds. In the presence of 5 mol% of Co(acac)3 catalyst, the desired products were obtained with exclusive substitution at the C5 position of the quinoline ring after 4 hours. The reaction shows high efficiency and good tolerance for a broad range of functional groups, affording the corresponding products in moderate to good yields.
Subject
Organic Chemistry,Catalysis
Cited by
13 articles.
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