Synthesis of Nepetoidin B

Author:

Timokhin Vitaliy1,Regner Matthew1ORCID,Tsuji Yukiko1,Grabber John2,Ralph John1

Affiliation:

1. Department of Energy Great Lakes Bioenergy Research Center and Department of Biochemistry, the Wisconsin Energy Institute, University of Wisconsin

2. U.S. Dairy Forage Research Center, USDA-ARS

Abstract

The first synthesis of nepetoidin B in an overall yield of 17% was achieved in two steps through Baeyer–Villiger oxidation of commercially available 1,5-bis(3,4-dimethoxyphenyl)-1,4-pentadien-3-one with oxone to produce the tetramethylated nepetoidin B, followed by demethylation using boron tribromide.

Funder

Biological and Environmental Research

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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