Affiliation:
1. Public Basic College, Bengbu Medical College, Bengbu,
China
2. College of pharmacy, Bengbu Medical College, Bengbu,
China
Abstract
AbstractEpilepsy is one of the most common encountered neurological disorders. Many
individuals continue to have seizures despite medical and surgical treatments,
suggesting new antiepileptic/anticonvulsant drugs are required. Triazole
compounds are widely used in pharmaceuticals and have gained significant
importance in medicinal chemistry. This article is an attempt to systematically
review the research of triazole derivatives in the design and development of
anticonvulsant agents during the past two decades through extensive literature
research. The results show that triazole occupy a distinct niche in heterocyclic
chemistry and represent a key motif in medicinal chemistry because of their
capability to exhibit an array of properties and bioactivities, Therefore,
1,2,4-triazole seems to be an important pharmacophore, especially in the field
of antiepileptic, which is of great explored potentiality and utilized value.
Through in-depth research on this type of structure, it is believed that more
1,2,4-triazole compounds will be developed as anti-epileptic drugs for clinical
use.
Funder
Science and Technology Project of Bengbu Medical College
Bengbu Medical College
Scientific Research Innovation Team Construction Project
Natural Science Fund projects of Bengbu Medical
College
Subject
Drug Discovery,General Medicine
Cited by
3 articles.
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