Earth-Abundant Transition Metal Catalyzed Asymmetric Hydrogenation of Minimally Functionalized Alkenes

Abstract

AbstractTransition-metal-catalyzed asymmetric hydrogenation (AH) is a growing field and a fundamental tool for the construction of chiral compounds. The use of earth-abundant transition metals in AH reactions remains generally limited but has received increased attention in recent years due to cost, sustainability, and environmental concerns. Here, we will summarize progress in first row transition metal catalyzed AH of minimally functionalized alkenes, including scope, mechanism, and challenges in this field.1 Introduction2 Ti-Catalyzed AH of Minimally Functionalized Alkenes3 Zr-Catalyzed AH of Minimally Functionalized Alkenes4 Co-Catalyzed AH of Minimally Functionalized Alkenes5 Fe-Catalyzed AH of Minimally Functionalized Alkenes6 Summary and Outlook