Affiliation:
1. Department of Chemistry and Biological Science, Aoyama Gakuin University
2. Department of Applied Chemistry, Chubu University
Abstract
AbstractWe report the iridium-catalyzed asymmetric allylation of indoles via kinetic resolution of 1-alken-4-yn-3-ols to form chiral 1-alken-4-yn-3-ols and branched allylated products with high selectivity. 1-Alken-4,6-diyn-3-ol was also found to be suitable for this asymmetric allylation and gave the products in high yield and enantioselectivity. Other nucleophiles such as a malonic ester and a thiol, besides indoles, reacted to give allylated products and 1-alken-4-yn-3-ols with high enantioselectivities.
Funder
Aoyama Gakuin University
Research Institute, Aoyama Gakuin University