Affiliation:
1. Department of Spinal Surgery, Shanghai East Hospital, Tongji University
School of Medicine, Shanghai, China
Abstract
Abstract
Purpose This study was aimed to discover the combined effects of single
nucleotide polymorphisms (SNPs) within the C-reactive protein (CRP) gene and
potential environmental factors on the risk and prognosis for diabetic foot
osteomyelitis (DFO).
Methods A total of 1734 diabetes mellitus patients, 681 with DFO and 1053
without DFO, were successfully recruited, as well as 1261 healthy control
individuals. Participants data were recorded regarding age, gender, smoking and
drinking history, body mass index (BMI), hypertension, cacosmia, and ulceration.
A total of 11 SNPs within the CRP gene were designated for exploration, by
logistic regression analyses, of how they might interact with environmental
factors to affect susceptibility to DFO.
Results Frequencies of smoking and drinking, and incidence of
hypertension, cacosmia, or ulceration displayed marked differences (all
P<0.05) between DFO and non-DFO patients. Furthermore, allele G
of rs11265260 (A>G), allele G of rs1800947 (C>G), and allele T
of rs3093059 (T>C) and rs1130864 (C>T) exhibited a trend to
increase risk of DFO (all P<0.05). Allele G of rs11265260
(A>G), allele G of rs1800947 (C>G) and rs3093068 (G>C),
and allele T of rs1130864 (C>T) were significant predictors of poor
prognosis among DFO patients (P<0.05). In addition, genotypes of
rs11265260 (i.e., GG and AG), rs1800947 (i.e., CG and GG), rs3093059 (i.e., TT)
and rs113084 (i.e., CT and TT) amplified the influence of smoking, alcohol
consumption, cacosmia, and ulceration on progression from non-DFO to DFO (all
γ>1).
Conclusion Genetic mutations within CRP functioned interactively with
external factors to affect DFO risk.
Funder
National Natural Science Foundation of China
Program for Young Excellent Talents in Pudong New Area health
system
Key Discipline Construction Project of Pudong Health Bureau of
Shanghai
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine