Visible-Light-Driven Selenyl-Radical-Mediated Cascade Spirocyclization of 3-(2-Isocyanobenzyl)indoles with Diselenides

Abstract

AbstractWe present a facile, visible-light-driven, selenyl-radical-mediated, cascade spirocyclization of 3-(2-isocyanobenzyl)indoles with diselenides that affords various selenylated spiro[indole-3,3′-quinoline] derivatives under mild conditions. This protocol has good functional-group tolerance and a broad substrate scope; both diaryl and dialkyl diselenides are tolerated.