Endoscopic submucosal dissection (ESD) for anal high-grade intraepithelial neoplasia: a case report

Author:

Neureiter Daniel1,Holzinger Josef2,Kiesslich Tobias3,Klieser Eckhard1,Berr Frieder4,Wagner Andrej4

Affiliation:

1. Institute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Salzburg, Austria

2. Department of Surgery, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Salzburg, Austria

3. Laboratory for Tumour Biology and Experimental Therapies (TREAT), Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria

4. Department of Internal Medicine I, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Salzburg, Austria

Abstract

AbstractAnal intraepithelial neoplasia (AIN) is a precursor of anal carcinoma. Conventional therapy is based on topical and local ablative approaches. However, the recurrence rates are very high, leading to repetitive treatment sessions and need for long-term surveillance. Endoscopic submucosal dissection (ESD) is an established treatment for malignant early neoplasias of the gastrointestinal tract, especially in the esophagus, stomach, and colorectum. Japanese centers have reported few cases of ESD for early anal carcinoma. We report a case of high-grade AIN diagnosed with magnifying narrow-band imaging and chromoendoscopy that was resected R0 with ESD en bloc.

Publisher

Georg Thieme Verlag KG

Subject

Gastroenterology

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1. Safety, feasibility, and short-term-outcome of anal endoscopic submucosal dissection for anal intraepithelial neoplasia: an option for focal lesions?;Techniques in Coloproctology;2023-12-15

2. Kolorektum: Mukosaneoplasien;Atlas Frühkarzinome des Gastrointestinaltrakts;2023

3. High-grade anal intraepithelial neoplasia treated with endoscopic submucosal dissection: a case report;Acta Gastro Enterologica Belgica;2022-03

4. Colorectum: Mucosal Neoplasias;Atlas of Early Neoplasias of the Gastrointestinal Tract;2019

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