Affiliation:
1. Worcester Polytechnic Institute
2. The Ohio State University
Abstract
AbstractA catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a variety of alkynes and chromanones. More than 40 substrates tested gave rise to >90% ee. Computational studies have indicated that the optimal indanyl ligand identified for most cases likely affords a network of supportive, non-covalent interactions that drive the enantioselective nature of the reaction.
Funder
National Institutes of Health
Subject
Organic Chemistry,Catalysis
Cited by
1 articles.
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