20.2.1.8.15 Synthesis of Carboxylic Acids with Retention of the Functional Group (Update 2024)

Abstract

AbstractCarboxylic acids are readily available feedstock materials, and are also found in natural products, pharmaceuticals, agrochemicals, and other biologically active compounds. Hence, efficient methods to transform carboxylic acids into other value-added compounds is of great importance. This review is an update to Science of Synthesis Section 20.2.1.8 on the synthesis of carboxylic acids with “retention of the functional group”. The main focus of this review is placed on asymmetric reactions and catalytic reactions, along with practical stoichiometric reactions, reported in the period 2010–2022. The transformations discussed include α-functionalizations, conjugate additions, and C(sp2)—H as well as C(sp3)—H functionalizations.