Affiliation:
1. Laboratory for Biomimetic Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute
2. Department of Chemistry and Centre for Biotechnology, Brock University
Abstract
AbstractA 7-step total synthesis of methyl 1,5,8-trimethoxy-1H-isochromene-3-carboxylate and a 5-step synthesis of its C-3 derivatives are reported. Sonogashira coupling of 2-halobenzaldehydes with terminal acetylenes was employed to access 2-alkynylbenzaldehydes, which underwent a Pd-catalyzed annulation to afford the corresponding isochromene-containing products.
Funder
Natural Sciences and Engineering Research Council of Canada
Canada Excellence Research Chairs, Government of Canada
Canada Foundation for Innovation
TDC Research
Ontario Partnership for Innovation and Commercialization General Information
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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