New Synthetic Approach to Protulactone A and Structural Analogues

Author:

Francuz Jovana1ORCID,Djokić Sanja1,Popsavin Mirjana1,Rodić Marko V.1,Kojić Vesna2,Krüger Biljana3,Popsavin Velimir14

Affiliation:

1. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection

2. University of Novi Sad, Faculty of Medicine, Oncology Institute of Vojvodina

3. University of Innsbruck, Institute of Mineralogy and Petrography

4. Serbian Academy of Sciences and Arts

Abstract

AbstractA new synthetic approach to protulactone A and several of its structural analogues, starting from d-galactose, has been developed. In a preliminary bioassay, all the compounds showed potent cytotoxicities. A structure–activity relationship analysis identified structural segments that are important for antiproliferative activity.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Serbian Academy of Sciences and Arts

Bundesministerium für Bildung, Wissenschaft und Forschung

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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