New Synthetic Approach to Protulactone A and Structural Analogues-Reference-Cited by-同舟云学术

New Synthetic Approach to Protulactone A and Structural Analogues

Published:2022-12-21 Issue: Volume: Page:
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Francuz Jovana¹^ORCID,Djokić Sanja¹,Popsavin Mirjana¹,Rodić Marko V.¹,Kojić Vesna²,Krüger Biljana³,Popsavin Velimir¹⁴

Affiliation:

1. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection

2. University of Novi Sad, Faculty of Medicine, Oncology Institute of Vojvodina

3. University of Innsbruck, Institute of Mineralogy and Petrography

4. Serbian Academy of Sciences and Arts

Abstract

AbstractA new synthetic approach to protulactone A and several of its structural analogues, starting from d-galactose, has been developed. In a preliminary bioassay, all the compounds showed potent cytotoxicities. A structure–activity relationship analysis identified structural segments that are important for antiproliferative activity.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Serbian Academy of Sciences and Arts

Bundesministerium für Bildung, Wissenschaft und Forschung

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1751400.pdf

Reference11 articles.

1. Marine fungal metabolites as a rich source of bioactive compounds

2. Protulactones A and B: Two New Polyketides from the Marine-derived Fungus Aspergillus sp. SF-5044

3. Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A

4. Stereoselective synthesis of (−)-protulactone A

5. Divergent total synthesis of crassalactones B and C and evaluation of their antiproliferative activity

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