Affiliation:
1. Technical Biochemistry, Biochemical and Chemical Engineering
2. MINDbioscience GmbH
Abstract
AbstractAn efficient synthesis of 2,5-dihydrobenzoxepine analogues was developed without using protecting groups. Regioselective allylation was optimized through a recent method utilizing magnesium dicarboxylates. Grubbs catalysts were applied to investigate ring-closing metathesis. The scope of the present route was extended to produce four analogues, which provided novel cannabinoid-like 2,5-dihydrobenzoxepines in sufficient quantities to permit in vitro assays on recombinant CB1/CB2 receptors. In vitro assays related to CB1/CB2 receptors did not indicate any activity.
Funder
Bundesministerium für Bildung und Forschung
Subject
Organic Chemistry,Catalysis