Oxidative C–H Sulfonylation of Hydrazones Enabled by Electrochemistry

Author:

Yang Qi-LiangORCID,Lei Ping-Ping,Guo Hai-Ming,Hao Er-Jun,Zhang Bei-Ning,Zhou Hong-Hao,Li Wan-Wan

Abstract

AbstractAn efficient electrochemical oxidative C(sp2)–H sulfonylation of aldehyde hydrazones is described. A variety of sodium sufinates or sulfinic acids participate effectively in this protocol, which provides facile access to an array of alkyl and aromatic sulfonylated hydrazones with up to 96% yield. Large-scale synthesis and product derivatization show the potential utility of this methodology. Preliminary mechanistic investigations including radical-inhibition, electricity on/off experiments, and cyclic voltammetry support a radical pathway.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Henan Normal University Initiation Fund

Henan Key Laboratory of Organic Functional Molecules and Drug Innovation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Materials Science (miscellaneous),Biomaterials,Catalysis

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