Affiliation:
1. Institute of Chemical Synthesis and Homogeneous Catalysis (ISQCH) Spanish National Research Council (CSIC)
2. Aragonese Foundation for Research & Development (ARAID)
Abstract
AbstractCascade processes are an attractive strategy to rapidly build molecular complexity and circumvent the need to isolate reaction intermediates, providing higher efficiencies into synthetic routes with lower environmental toll. We have recently developed a new method to synthesise chiral 1,4-nitro alcohols by sequentially combining three transformations in the same reaction vessel via asymmetric C–C bond formation using a chiral thiourea catalyst and a bioreduction process as key steps.1 Introduction2 A Chemoenzymatic Cascade to Make Chiral 1,4-Nitro Alcohols3 Conclusions and Perspectives
Funder
Agencia Estatal de Investigación
Ministerio de Ciencia e Innovación
Fundación Agencia Aragonesa para la Investigación y el Desarrollo