Affiliation:
1. School of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering
2. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University
Abstract
AbstractReductive amination has not been commonly used in the preparation of N-alkylsulfonamides because of the low nucleophilicity of sulfonamides. In this work, a protocol for the synthesis of N-alkylsulfonamides from aldehydes or ketones and sulfonamides was developed. Molecular iodine, triethylsilane, and ethyl acetate were used as the initiator, reductant, and solvent, respectively. The key role of triethyl(iodo)silane in the reaction was confirmed through control experiments.
Funder
Open Project Program of Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province
Natural Science Foundation of Sichuan Province