Affiliation:
1. Department of Chemistry, Indian Institute of Technology Guwahati
2. Centre for Sustainable Polymers, Indian Institute of Technology Guwahati
Abstract
AbstractA boronic acid catalyzed one-pot reduction of quinolines with Hantzsch ester followed by N-arylation via external base-free Chan–Evans–Lam coupling has been demonstrated. This step-economical synthesis of N-aryl tetrahydroquinolines has been accomplished from readily available quinoline, Hantzsch ester, and arylboronic acid under mild reaction conditions. The dual role of boronic acid as a catalyst (in the reduction of quinolines) and a reagent (in the N-arylation) has been realized for the first time. The use of an inexpensive N-arylation protocol, aerobic reaction conditions, and functional group diversity are important practical features.
Funder
Science and Engineering Research Board
Department of Science and Technology
DST-INSPIRE
Cited by
3 articles.
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