Affiliation:
1. Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa
2. Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology
Abstract
AbstractA transesterification of methyl esters with aliphatic alcohols was developed using Ni/dcype catalysis. This reaction features the cleavage of the strong C(acyl)–OMe bond in the absence of acidic or basic additives, providing volatile methanol as the only stoichiometric waste product. A wide range of (hetero)aromatic and aliphatic methyl esters can be converted into the corresponding functionalized esters in good to excellent yields with high efficiency. Compared with traditional transesterifications, this cross-coupling approach offers new opportunities for efficient and chemoselective synthesis.
Funder
Natural Sciences and Engineering Research Council of Canada
National Natural Science Foundation of China
Canada Research Chairs
Canada Foundation for Innovation
Ontario Ministry of Research, Innovation and Science
Tianjin University of Technology