New Dephenylated Analogues of (–)-Goniofufurone: Optimization of Synthesis from l-Xylose-Reference-Cited by-同舟云学术

New Dephenylated Analogues of (–)-Goniofufurone: Optimization of Synthesis from l-Xylose

Published:2024-06-25 Issue: Volume: Page:
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Zelenović Bojana Srećo¹,Stanisavljević Sladjana¹^ORCID,Popsavin Mirjana¹,Kojić Vesna²,Benedeković Goran¹,Popsavin Velimir

Affiliation:

1. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry, and Environmental Protection

2. University of Novi Sad, Faculty of Medicine, Oncology Institute of Vojvodina

Abstract

AbstractNatural products containing highly oxygenated furanofuranone fragments are known for their potent biological activity, but also for their challenging total synthesis. In this study, the synthesis of five novel dephenylated (–)-goniofufurone analogues was completed and their cytotoxic activity against eight malignant and one normal human cell line was evaluated. Compared with previous syntheses of similar analogues, the synthesis was carried out starting from l-xylose, resulting in improved yields and a reduced number of synthetic steps for three divergent intermediates.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Serbian Academy of Sciences and Arts

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2352-9691.pdf

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