Multidrug resistance 1 (MDR1) gene mutation in dogs

Abstract

The multidrug resistance (MDR1) gene mutation in the domestic dog (Canis lupus familiaris) is an inherited condition most frequently observed in herding breeds. Dogs with the mutated gene are at risk of neurological toxicosis and life-threatening reactions if certain drugs are administered. Determining the MDR1 genotype of a dog via blood or buccal swab sampling will assist owners and veterinary professionals in understanding their risk of multidrug sensitivity. Some of the drugs known to be dangerous when administered to a dog with the mutation are used in everyday practice. To ensure patient safety, the student and registered veterinary nurse should have an understanding of this condition, particularly when dealing with the dog breeds at higher risk. This article aims to provide student and registered veterinary nurses with a comprehensive and logical analysis of the MDR1 gene mutation in dogs.