Understanding the pharmacology of heart failure

Abstract

The prevalence of heart failure is increasing worldwide. Jamshid Easa, Najma Easa, Jacob Chappell and David Warriner provide an overview of the pharmacology of the drugs used to manage the condition Heart failure (HF) is a common clinical syndrome with ever-increasing prevalence in the Western world. It is associated with extensive morbidity and mortality, as well as being a significant burden on global healthcare systems. It is due to impairment of ventricular filling or contraction, resulting in a constellation of physical symptoms and signs, primarily due to salt and water retention. An understanding of the pharmacological options to manage the condition is imperative to quickly alleviate symptoms and avert a rapidly progressive downward spiral, improving not only quality but also quantity of life.