Polypharmacy, renal insufficiency and elder care: a systematic review

Abstract

The incidence of comorbidities increases as individuals age, and many people are treated with multiple medications, referred to as polypharmacy. When individuals are prescribed more than two nephrotoxic medicines, renal insufficiency may result. Preventing overprescription is, therefore, especially important, particularly for older people who have an increased risk for developing irreversible renal insufficiency leading to chronic kidney disease. This systematic review appraised the influence of polypharmacy on renal insufficiency in older people