Lyophilised tilapia skin as a xenograft for superficial partial thickness burns: a novel preparation and storage technique

Author:

Júnior Edmar Maciel Lima1,de Moraes Filho Manoel Odorico2,Costa Bruno Almeida2,Alves Ana Paula Negreiros Nunes3,de Moraes Maria Elisabete Amaral2,do Nascimento Uchôa Alex Marques1,Martins Camila Barroso2,de Jesus Pinheiro Gomes Bandeira Tereza4,Rodrigues Felipe Augusto Rocha25,Paier Carlos Roberto Koscky2,Lima Felipe Crescencio4,Júnior Francisco Raimundo Silva1

Affiliation:

1. Burn Treatment Center, Dr José Frota Institute, Fortaleza, CE, Brazil

2. Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil

3. Nursing, Dentistry and Pharmacy School of the Federal University of Ceará, Fortaleza, CE, Brazil

4. Christus University Center, Fortaleza, CE, Brazil

5. Federal Institute of Education, Science and Technology of Ceará (IFCE)—Campus Jaguaribe, CE, Brazil

Abstract

Despite a considerable decrease in its incidence worldwide, burns remain the fourth most common type of trauma. The majority of burns are small, with 75% of injuries treated on an outpatient basis. Tilapia skin, as a biological material, has been suggested as an option for the management of burn wounds. After good results were obtained with the use of a glycerolised version of tilapia skin in burned children and adults, it was hypothesised that similar outcomes could be achieved with the use of a lyophilised version of tilapia skin. We report the case of a 33-year-old female patient with scalds to the upper abdomen, and both breasts, arms and forearms. Involvement of 10% of total body surface area with superficial partial thickness burns was calculated. The good adherence of tilapia skin to the wound bed, a 10-day period for complete re-epithelialisation of the wounds and the absence of side effects suggested that the lyophilised version of tilapia skin is effective for burn treatment. Compared with glycerolisation, lyophilisation is thought to permit extended storage of sterile tissue and decreased costs related to distribution and transport, but further studies are needed to confirm this.

Publisher

Mark Allen Group

Subject

Nursing (miscellaneous),Fundamentals and skills

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