Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach

Author:

Boisdron-Celle Michele,Capitain Olivier,Faroux Roger,Borg Christophe,Metges Jean Philippe,Galais Marie Pierre,Kaassis Mehdi,Bennouna Jaafar,Bouhier-Leporrier Karine,Francois Eric,Baumgaertner Isabelle,Guerin-Meyer Véronique,Cojocarasu Oana,Roemer-Becuwe Celia,Stampfli Claire,Rosenfeld Ludovic,Lecompte Thierry,Berger Virginie,Morel Alain,Gamelin Erick

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference58 articles.

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2. Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a randomized trial;Andre;J Clin Oncol,2003

3. Dihydropyrimidine dehydrogenase: its role in 5fFluorouracil clinical toxicity and tumor resistance;Diasio;Clin Cancer Res,1999

4. Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy;Lee;Clin Adv Hematol Oncol,2004

5. Clinical implication of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-Fluorouracil-associated toxicity: identification of new mutations in the DPD gene;van Kuilenburg;Clin Cancer Res,2000

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