Monitoring the Hematologic Complications of Cardiopulmonary Bypass

Abstract

Patients undergoing cardiopulmonary bypass (CPB) procedures have a variety of hemostatic defects that lead to bleeding and the frequent need for transfusion of allogeneic blood products. Dilution of the patient's blood volume by the extracorporeal circuit priming so lution causes depletion of platelets and coagulation factor levels. Contact of blood with the extracorporeal circuit induces a hemorrhagic diathesis through a vari ety of mechanisms. Contact activation causes the for mation of kallikrein, bradykinin, and complement acti vation, leading to a whole-body inflammatory reaction. Intrinsic coagulation is stimulated, leading to subse quent activation of the fibrinolytic system. Platelet dys function caused by the effects of the extracorporeal circuit on platelet membrane integrity and the effects of circulating platelet inhibitors have also been described. The use of high-dose heparin for CPB mitigates these effects but does not completely eliminate them. Prota mine, administered to antagonize heparin's effects, has antiplatelet properties and anticoagulant effects when given in excess. Because of the numerous hemostatic insults incurred during and after CPB, complex moni toring techniques are necessary to ensure adequate anticoagulation, adequate heparin neutralization, and normal platelet function. Coagulation monitoring has allowed more specific identification of particular distur bances of hemostasis and has been linked with a reduc tion in hemorrhagic complications after CPB. Copyright © 2001 by W.B. Saunders Company.