Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants

Author:

Debiec-Rychter Maria,Cools Jan,Dumez Herlinde,Sciot Raf,Stul Michel,Mentens Nicole,Vranckx Hilde,Wasag Bartosz,Prenen Hans,Roesel Johannes,Hagemeijer Anne,Van Oosterom Allan,Marynen Peter

Publisher

Elsevier BV

Subject

Gastroenterology,Hepatology

Reference28 articles.

1. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors;Hirota;Science,1998

2. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors;Rubin;Cancer Res,2001

3. PDGFRA activating mutations in gastrointestinal stromal tumors;Heinrich;Science,2003

4. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal tumors;Van Oosterom;Lancet,2001

5. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors;Demetri;N Engl J Med,2002

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