Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease

Author:

Leibovitzh Haim,Lee Sun-Ho,Xue Mingyue,Raygoza Garay Juan Antonio,Hernandez-Rocha Cristian,Madsen Karen L.,Meddings Jonathan B.,Guttman David S.,Espin-Garcia Osvaldo,Smith Michelle I.,Goethel Ashleigh,Griffiths Anne M.,Moayyedi Paul,Steinhart A. Hillary,Panaccione Remo,Huynh Hien Q.,Jacobson Kevan,Aumais Guy,Mack David R.,Abreu Maria T.,Bernstein Charles N.,Marshall John K.,Turner Dan,Xu Wei,Turpin Williams,Croitoru KennethORCID

Publisher

Elsevier BV

Subject

Gastroenterology,Hepatology

Reference59 articles.

1. The intestinal barrier: a fundamental role in health and disease;Vancamelbeke;Expert Rev Gastroenterol Hepatol,2017

2. The intestinal epithelial barrier: a therapeutic target?;Odenwald;Nat Rev Gastroenterol Hepatol,2017

3. Increased gastric and intestinal permeability in patients with Crohn’s disease;Wyatt;Am J Gastroenterol,1997

4. Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?;Söderholm;Gut,1999

5. Impaired intestinal permeability contributes to ongoing bowel symptoms in patients with inflammatory bowel disease and mucosal healing;Chang;Gastroenterology,2017

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