Methylation Tolerance-Based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome

Author:

Bouvet Delphine,Bodo SahraORCID,Munier Annie,Guillerm Erell,Bertrand Romane,Colas Chrystelle,Duval Alex,Coulet Florence,Muleris MartineORCID

Funder

Ligue Contre le Cancer

Publisher

Elsevier BV

Subject

Gastroenterology,Hepatology

Reference45 articles.

1. Milestones of Lynch syndrome: 1895–2015;Lynch;Nat Rev Cancer,2015

2. Mismatch binding proteins and tolerance to alkylating agents in human cells;Karran;Mutat Res,1990

3. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage;Karran;Nucleic Acids Res,1992

4. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint;Hawn;Cancer Res,1995

5. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair;Kat;Proc Natl Acad Sci U S A,1993

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