Interaction Between Amiodarone and Sofosbuvir-based Treatment for Hepatitis C Virus Infection: Potential Mechanisms and Lessons to be Learned

Author:

Back David J.,Burger David M.

Publisher

Elsevier BV

Subject

Gastroenterology,Hepatology

Reference11 articles.

1. Anonymous. FDA warns of serious slowing of the heart rate when the antiarrhythmic drug amiodarone us used with hepatitis C treatments containing sofosbuvir (Harvoni) or Sovaldi in combination with another Direct Acting Antiviral drug. Available from: www.fda.gov; accessed May 17, 2015.

2. Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge;Renet;Gastroenterology,2015

3. Anonymous. IMPORTANT DRUG WARNING. Serious and life-threatening cases of symptomatic bradycardia as well as one case of fatal cardiac arrest reported with coadministration of amiodarone with either Harvoni® (ledipasvir and sofosbuvir fixed-dose combination) or with Sovaldi® (sofosbuvir) in combination with another direct acting antiviral. Dear Healthcare Provider letter. Gilead Sciences, March 20, 2015.

4. A method for estimating the probability of adverse drug reactions;Naranjo;Clin Pharmacol Ther,1981

5. Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia;Van Herendael;Vasc Health Risk Manag,2010

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