Ursodeoxycholic acid (UDCA) prevents DCA effects on male mouse liver via up-regulation of CXP and preservation of BSEP activities

Author:

Paolini Moreno,Pozzetti Laura,Montagnani Marco,Potenza Giuseppa,Sabatini Laura,Antelli Alessandra,Cantelli-Forti Giorgio,Roda Aldo

Funder

MURST (Ministry of the University and of the Scientific and Technological Research of Italy), CIB (Interuniversity Biotechnology Center, Bologna), and Fondazione Cassa di Risparmio in Bologna

Publisher

Wiley

Subject

Hepatology

Reference40 articles.

1. Mechanism of cholestasis. 2. Effect of bile acids on microsomal cytochrome P450-dependent biotransformation system in vivo;Hutterer;Life Sci,1970

2. Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: relevance to drug metabolism in experimental cholestasis;Chen;J Gastroenterol Hepatol,1996

3. Down-regulation of male-specific cytochrome P450s 2C11 and 3A2 in bile duct-ligated male rats; importance to reduced hepatic content of cytochrome P450 cholestasis;Chen;Hepatology,1995

4. Mechanism of cholestasis. 4. Structural and biochemical changes in the liver and serum in rats after bile duct-ligation;Schaffner;Gastroenterology,1971

5. Ursodeoxycholate (UDC) prevents the hepatocellular damage caused by other bile salts as its conjugates in rats;Kitani;Hepatology,1988

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