Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex

Author:

Clay-Gilmour Alyssa I.1,Hahn Theresa2,Preus Leah M.3,Onel Kenan4,Skol Andrew5,Hungate Eric5,Zhu Qianqian6,Haiman Christopher A.7,Stram Daniel O.7,Pooler Loreall7,Sheng Xin7,Yan Li6,Liu Qian8,Hu Qiang6,Liu Song6,Battaglia Sebastiano9,Zhu Xiaochun10,Block AnneMarie W.11,Sait Sheila N. J.11,Karaesmen Ezgi3,Rizvi Abbas3,Weisdorf Daniel J.12,Ambrosone Christine B.13,Tritchler David8,Ellinghaus Eva14,Ellinghaus David14,Stanulla Martin15,Clavel Jacqueline1617,Orsi Laurent1617,Spellman Stephen18,Pasquini Marcelo C.10,McCarthy Philip L.2,Sucheston-Campbell Lara E.319

Affiliation:

1. Department of Cancer Genetic Epidemiology, Mayo Clinic, Rochester, MN;

2. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY;

3. College of Pharmacy, The Ohio State University, Columbus, OH;

4. Department of Pediatrics, Northwell Health, Great Neck, NY;

5. Department of Pediatrics, The University of Chicago, Chicago, IL;

6. Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY;

7. Department of Preventive Medicine, University of Southern California, Los Angeles, CA;

8. Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY;

9. Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY;

10. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

11. Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, NY;

12. Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN;

13. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY;

14. Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany;

15. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hanover, Germany;

16. Epidemiology and Biostatistics Sorbonne Paris Cité Centre, INSERM U1153, Paris, France;

17. Epidemiology of Childhood and Adolescent Cancers Team, Paris Descartes University, Paris, France;

18. Center for International Blood and Marrow Transplant Research, Minneapolis, MN; and

19. College of Veterinary Medicine, The Ohio State University, Columbus, OH

Abstract

Key Points IKZF1 associations with high-risk B-ALL may differ by age and sex. A novel variant on chromosome 14, rs189434316, is associated with over a 3.5-fold risk of normal cytogenetic B-ALL.

Publisher

American Society of Hematology

Subject

Hematology

Reference79 articles.

1. National Cancer Institute. Adult acute lymphoblastic leukemia treatment (PDQ)–health professional version. Updated 17 April 2015. http://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq. Accessed 28 July 2015.

2. National Cancer Institute Surveillance, Epidemiology, and End Results Program. Cancer statistics. Available at: http://seer.cancer.gov. Accessed 5 April 2016.

3. Acute lymphoblastic leukaemia;Inaba;Lancet,2013

4. Lifestyle factors and the risk of adult leukemia in Canada;Kasim;Cancer Causes Control,2005

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