Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma-Reference-Cited by-同舟云学术

Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma

Published:2019-10-21 Issue:20 Volume:3 Page:3020-3032
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Stelling Anna¹,Wu Cheuk-Ting¹,Bertram Katrin¹,Hashwah Hind¹^ORCID,Theocharides Alexandre P. A.²³,Manz Markus G.²³,Tzankov Alexandar⁴,Müller Anne¹³

Affiliation:

1. Institute of Molecular Cancer Research, Zurich, Switzerland;

2. Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland;

3. Comprehensive Cancer Center Zurich, Zurich, Switzerland; and

4. Institute of Pathology, University Hospital Basel, Basel, Switzerland

Abstract

Key Points SMAD1 is silenced by hypermethylation in DLBCL cell lines and patient samples but not in peripheral blood B cells or lymph nodes. DAC treatment restores SMAD1 expression and reverses DLBCL growth in several xenotransplantation and patient-derived xenograft models.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/20/3020/1502351/advancesadv2019000210.pdf

Reference34 articles.

1. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes [published corrections appear in Nat. Med. 2018;24(8):1290-1291; Nat. Med. 2018;24(8):1292];Chapuy;Nat Med,2018

2. Genetics and pathogenesis of diffuse large B-cell lymphoma;Schmitz;N Engl J Med,2018

3. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling;Alizadeh;Nature,2000

4. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma;Rosenwald;N Engl J Med,2002

5. A multiprotein supercomplex controlling oncogenic signalling in lymphoma;Phelan;Nature,2018

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