In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL-Reference-Cited by-同舟云学术

In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL

Published:2018-05-31 Issue:11 Volume:2 Page:1229-1242
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Fiedler Eleanor R. C.¹,Bhutkar Arjun¹,Lawler Emily¹,Besada Rana¹,Hemann Michael T.¹

Affiliation:

1. The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA

Abstract

Key Points Functional in vivo screening reveals distinct genetic dependencies in a mouse model of BCR-ABL1+ BCP-ALL after dasatinib treatment. Disruption of the PAF/PAFR/PAFAH1B axis sensitizes leukemia cells to TKIs; this pathway may be a novel target for combination therapy.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/11/1229/881845/advances015610.pdf

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