Bendamustine-induced immune hemolytic anemia: a case report and systematic review of the literature

Author:

Chan Maverick1,Silverstein William K.2ORCID,Nikonova Anna1,Pavenski Katerina123,Hicks Lisa K.124

Affiliation:

1. Division of Hematology-Oncology, St. Michael’s Hospital, Toronto, ON, Canada;

2. Department of Medicine and

3. Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada; and

4. Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada

Abstract

Key Points Bendamustine can cause severe autoimmune hemolytic anemia (AIHA), which may require plasma exchange and aggressive immunosuppression. Bendamustine-induced AIHA can be delayed, and many, but not all, cases report prior exposure to fludarabine.

Publisher

American Society of Hematology

Subject

Hematology

Reference24 articles.

1. Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review;Ahrens;Am J Hematol,2006

2. Immune hemolytic anemia associated with drug therapy;Garratty;Blood Rev,2010

3. Variability of the erythropoietic response in autoimmune hemolytic anemia: analysis of 109 cases;Liesveld;Blood,1987

4. Drug-induced immune hemolytic anemia;Salama;Expert Opin Drug Saf,2009

5. Alberta Health Services. Lymphoma. Clinical practice guideline LYHE-002 version 12. albertahealthservices.ca/assets/info/hp/cancer/if-hp-cancer-guide-lyhe002-lymphoma.pdf. Accessed 21 September 2019.

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