A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms-Reference-Cited by-同舟云学术

A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms

Published:2018-07-20 Issue:14 Volume:2 Page:1719-1737
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Martínez-Laperche Carolina¹²,Buces Elena¹²,Aguilera-Morillo M. Carmen³,Picornell Antoni²⁴,González-Rivera Milagros⁴⁵,Lillo Rosa³,Santos Nazly⁶,Martín-Antonio Beatriz⁷,Guillem Vicent⁸,Nieto José B.⁹,González Marcos¹⁰,de la Cámara Rafael¹¹,Brunet Salut¹²,Jiménez-Velasco Antonio¹³,Espigado Ildefonso¹⁴,Vallejo Carlos¹⁵,Sampol Antonia¹⁶,Bellón José María²,Serrano David¹²,Kwon Mi¹²,Gayoso Jorge¹²,Balsalobre Pascual¹²,Urbano-Izpizua Álvaro⁷,Solano Carlos⁸,Gallardo David⁶,Díez-Martín José Luis¹²¹⁷,Romo Juan³,Buño Ismael¹²¹⁸

Affiliation:

1. Department of Hematology, Hospital General Universitario (H.G.U.) Gregorio Marañón, Madrid, Spain;

2. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain;

3. Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain;

4. Department of Oncology and

5. DNA Sequencing and Genotyping Core Facility, H.G.U. Gregorio Marañón, Madrid, Spain;

6. Department of Hematology, Instituto Catalán de Oncología Hospital Josep Trueta, Girona, Spain;

7. Department of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain;

8. Department of Hematology, Hospital Clínico de Valencia, Valencia, Spain;

9. Department of Hematology, Hospital Universitario Morales Meseguer, Murcia, Spain;

10. Department of Hematology, Hospital de Salamanca, Salamanca, Spain;

11. Department of Hematology, Hospital Universitario de La Princesa, Madrid, Spain;

12. Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

13. Department of Hematology, Hospital Regional de Málaga, Málaga, Spain;

14. Department of Hematology, Hospital Universitario Virgen del Rocío, Seville, Spain;

15. Department of Hematology, Hospital Central de Asturias, Oviedo, Spain;

16. Department of Hematology, Hospital Universitario Son Espases, Palma de Mallorca, Spain;

17. Department of Medicine, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain; and

18. Genomics Unit, H.G.U. Gregorio Marañón/Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Abstract

Key Points A risk model using donor and recipient cytokine gene polymorphisms and clinical variables significantly improves GVHD risk stratification. The model is useful in identifying patients with low-risk of developing severe GVHD, but results must be confirmed in prospective studies.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/14/1719/881097/advances011502.pdf

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