M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion-Reference-Cited by-同舟云学术

M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion

Published:2018-04-17 Issue:8 Volume:2 Page:859-870
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Luo Yi¹²,Shao Lijian¹,Chang Jianhui¹,Feng Wei¹,Liu Y. Lucy³,Cottler-Fox Michele H.⁴,Emanuel Peter D.³,Hauer-Jensen Martin¹,Bernstein Irwin D.⁵,Liu Lingbo⁶,Chen Xing²,Zhou Jianfeng²,Murray Peter J.⁷⁸⁹,Zhou Daohong¹¹⁰

Affiliation:

1. Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR;

2. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

3. Department of Medicine and

4. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR;

5. Clinical Division, Department of Pediatric Oncology, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

7. Department of Infectious Diseases and

8. Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN;

9. Max Planck Institute of Biochemistry, Martinsried, Germany; and

10. Department of Pharmacodynamics, College of Pharmacy, University of Florida at Gainesville, Gainesville, FL

Abstract

Key Points M2-MΦs promote and M1-MΦs inhibit HSC self-renewal via differential expression of Arg1 and NOS2, respectively. Coculture of hUCB CD34+ cells with M2-MΦs resulted in a significant expansion of CD34+ cells and SCID–mice repopulating cells.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/8/859/880831/advances015685.pdf

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