Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets

Author:

Battinelli Elisabeth M.12,Thon Jonathan N.123,Okazaki Ross1,Peters Christian G.234,Vijey Prakrith1,Wilkie Adrian R.12,Noetzli Leila J.12,Flaumenhaft Robert24,Italiano Joseph E.125

Affiliation:

1. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA;

2. Harvard Medical School, Boston, MA;

3. Platelet Biogenesis, Cambridge, MA;

4. Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA; and

5. Vascular Biology Program, Department of Surgery, Children’s Hospital Boston, Boston, MA

Abstract

Key Points Mouse megakaryocytes can differentially sort and package endocytosed fibrinogen and endostatin into distinct α-granules. Platelet progenitors contain subpopulations of α-granules.

Publisher

American Society of Hematology

Subject

Hematology

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