ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model-Reference-Cited by-同舟云学术

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Published:2017-08-08 Issue:18 Volume:1 Page:1452-1465
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Greineder Colin F.¹^ORCID,Johnston Ian H.¹²,Villa Carlos H.¹³,Gollomp Kandace²,Esmon Charles T.⁴⁵,Cines Douglas B.³,Poncz Mortimer¹²,Muzykantov Vladimir R.¹

Affiliation:

1. Department of Systems Pharmacology and Translational Therapeutics and

2. Division of Hematology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

4. Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK; and

5. Department of Pathology and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

Abstract

Key PointsA microfluidic model of TF-driven thrombosis allows testing of human-specific, antibody-targeted therapeutics in whole blood under flow. hTM/R6.5 inhibits inflammatory thrombosis more effectively than untargeted agents (eg, shTM) and shows synergy with supplemental PC.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/18/1452/878458/advances007229.pdf

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