High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis-Reference-Cited by-同舟云学术

High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis

Published:2017-03-21 Issue:9 Volume:1 Page:535-544
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Lombardo Katharine A.¹²^ORCID,Coffey David G.¹³^ORCID,Morales Alicia J.¹,Carlson Christopher S.⁴^ORCID,Towlerton Andrea M. H.¹,Gerdts Sarah E.⁵,Nkrumah Francis K.⁶,Neequaye Janet⁷,Biggar Robert J.⁸,Orem Jackson⁹^ORCID,Casper Corey¹³⁴⁵¹⁰^ORCID,Mbulaiteye Sam M.¹¹,Bhatia Kishor G.¹¹,Warren Edus H.¹³^ORCID

Affiliation:

1. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Molecular and Cellular Biology Program and

3. Department of Medicine, School of Medicine, University of Washington, Seattle, WA;

4. Division of Public Health Sciences and

5. Division of Vaccine and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Noguchi Institute for Medical Research and

7. Department of Child Health, Medical School, University of Ghana, Accra, Ghana;

8. Institute of Health and Biotechnical Innovation, Queensland University of Technology, Brisbane, QLD, Australia;

9. Uganda Cancer Institute, Kampala, Uganda;

10. Department of Global Health, School of Medicine, and

11. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points High-throughput sequencing of primary African Burkitt lymphoma tumors suggests disrupted immunoglobulin rearrangements in BL progenitors. Extensive mutation of expressed and nonexpressed IGH rearrangements suggests multiple active mutational processes in BL tumors.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/9/535/878301/advances000794.pdf

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5. Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men;Müller;Proc Natl Acad Sci USA,1995

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