Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts

Author:

Saraf Santosh L.1ORCID,Akingbola Titilola S.2,Shah Binal N.1,Ezekekwu Chinedu A.2,Sonubi Omowunmi2,Zhang Xu1,Hsu Lewis L.3,Gladwin Mark T.45,Machado Roberto F.6,Cooper Richard S.7,Gordeuk Victor R.1,Tayo Bamidele O.7ORCID

Affiliation:

1. Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL;

2. Department of Hematology, University College Hospital, Ibadan, Nigeria;

3. Division of Hematology and Oncology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL;

4. Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and

5. Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA;

6. Division of Pulmonary and Critical Care, Department of Medicine, University of Illinois at Chicago, Chicago, IL; and

7. Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL

Abstract

Key Points A genetic risk profile integrating α-thalassemia and BCL11A status improves associations with hemolytic markers and stroke history.

Publisher

American Society of Hematology

Subject

Hematology

Reference34 articles.

1. Global epidemiology of haemoglobin disorders and derived service indicators;Modell;Bull World Health Organ,2008

2. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration;Maller;Nat Genet,2006

3. Polygenic determinants of severe hypertriglyceridemia;Wang;Hum Mol Genet,2008

4. The interaction of alpha-thalassemia and homozygous sickle-cell disease;Higgs;N Engl J Med,1982

5. Evidence that microdeletions in the alpha globin gene protect against the development of sickle cell glomerulopathy in humans;Guasch;J Am Soc Nephrol,1999

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