Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia

Author:

Kovacsovics Tibor J.1,Mims Alice2,Salama Mohamed E.13,Pantin Jeremy4,Rao Narayanam1,Kosak Ken M.1,Ahorukomeye Peter1,Glenn Martha J.1,Deininger Michael W. N.1,Boucher Kenneth M.5,Bavisotto Linda M.6,Gutierrez-Sanchez Gerardo7,Kennedy Thomas P.8,Marcus Stephen G.9,Shami Paul J.1

Affiliation:

1. Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;

2. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;

3. Department of Pathology and Associated Regional and University Pathologists Laboratories, University of Utah, Salt Lake City, UT;

4. Division of Hematology/Oncology, Augusta University, Augusta, GA;

5. Department of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;

6. Porta Clinica PLLC, Seattle, WA;

7. Complex Carbohydrate Research Center, University of Georgia, Athens, GA;

8. Division of Pulmonary Medicine, Wake Forest University, Winston-Salem, NC; and

9. Cantex Pharmaceuticals, Weston, FL

Abstract

Key Points In a pilot study, the nonanticoagulant heparin derivative CX-01 was well tolerated when combined with chemotherapy for the treatment of AML. Preliminary results show encouraging complete remission rates and rapid platelet recovery.

Publisher

American Society of Hematology

Subject

Hematology

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