Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

Author:

Zufferey Anne1,Speck Edwin R.1,Machlus Kellie R.23,Aslam Rukhsana1,Guo Li1,McVey Mark J.14,Kim Michael1,Kapur Rick15,Boilard Eric6,Italiano Joseph E.237,Semple John W.1589

Affiliation:

1. Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada;

2. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA;

3. Harvard Medical School, Boston, MA;

4. Departments of Anesthesia and Physiology, University of Toronto, Toronto, ON, Canada;

5. Canadian Blood Services, Toronto, ON, Canada;

6. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Département de Microbiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC, Canada;

7. Vascular Biology Program, Department of Surgery, Children’s Hospital Boston, Boston, MA;

8. Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; and

9. Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden

Abstract

Key Points Megakaryocytes process and present endogenous/exogenous antigens on MHC class I molecules to activate CD8+ T cells. Megakaryocytes can transfer MHC class I molecules loaded with foreign antigen to proplatelets in vitro.

Publisher

American Society of Hematology

Subject

Hematology

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